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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | D(1A) dopamine receptor | ||
| Ligand | BDBM289097 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Human D1 Receptor Binding Assay | ||
| pH | 7.4±n/a | ||
| Ki | 8.54±n/a nM | ||
| Comments | extracted | ||
| Citation |  Brodney, MA; Davoren, JE; Dounay, AB; Efremov, IV; Gray, DL; Green, ME; Henderson, JL; Lee, C; Mente, SR; O Neil, SV; Rogers, BN; Zhang, L Heteroaromatic compounds and their use as dopamine D1 ligands US Patent US10093655 Publication Date 10/9/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| D(1A) dopamine receptor | |||
| Name: | D(1A) dopamine receptor | ||
| Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 49303.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21728 | ||
| Residue: | 446 | ||
| Sequence: |
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| BDBM289097 | |||
| n/a | |||
| Name | BDBM289097 | ||
| Synonyms: | (−)-1,5-Dimethyl-6-(2-methyl-4-{[3-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)pyrimidine-2,4(1H,3H)-dione (7) | US10093655, Example 7 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H15F3N3O3 | ||
| Mol. Mass. | 390.3359 | ||
| SMILES | Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)nc(=O)n1C |(-14.73,-19.08,;-14.73,-20.62,;-16.07,-21.39,;-16.07,-22.93,;-17.4,-23.7,;-17.4,-25.24,;-16.07,-26.01,;-16.07,-27.55,;-17.4,-28.32,;-18.74,-27.55,;-18.74,-26.01,;-20.07,-25.24,;-21.4,-26.01,;-20.07,-23.7,;-20.07,-26.78,;-14.73,-23.7,;-13.4,-22.93,;-13.4,-21.39,;-12.07,-20.62,;-12.07,-19.08,;-13.4,-18.31,;-10.73,-18.31,;-10.73,-16.77,;-9.4,-19.08,;-9.4,-20.62,;-8.07,-21.39,;-10.73,-21.39,;-10.73,-22.93,)| | ||
| Structure | 
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