| Reaction Details |
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 | Report a problem with these data |
| Target | 3-phosphoinositide-dependent protein kinase 1 [50-359] |
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| Ligand | BDBM50433916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Isothermal titration calorimetry |
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| pH | 7.4±n/a |
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| Kd | 1250±0.0 nM |
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| Comments | extracted |
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| Citation |  Schulze, JO; Saladino, G; Busschots, K; Neimanis, S; Süß, E; Odadzic, D; Zeuzem, S; Hindie, V; Herbrand, AK; Lisa, MN; Alzari, PM; Gervasio, FL; Biondi, RM Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol23:1193-1205 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-phosphoinositide-dependent protein kinase 1 [50-359] |
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| Name: | 3-phosphoinositide-dependent protein kinase 1 [50-359] |
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| Synonyms: | 3-Phosphoinositide dependent protein kinase-1 | PDK1 | PDPK1 | PDPK1_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 35373.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15530[50-359] |
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| Residue: | 310 |
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| Sequence: | AMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYA
IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK
YIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKV
LSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYL
IFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWEN
LHQQTPPKLT
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| BDBM50433916 |
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| n/a |
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| Name | BDBM50433916 |
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| Synonyms: | PS653 ('1,6-dihydrodibenzo[c,d,g]indazol-6-one) | SP-600125 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H8N2O |
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| Mol. Mass. | 220.2261 |
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| SMILES | O=C1c2ccccc2-c2[nH]nc3cccc1c23 |
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| Structure | 
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