| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
|---|
| Ligand | BDBM199128 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | enzyme-based fluorimetric assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 42.26±0.32 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Zheng, XZ; Zhou, JL; Ye, J; Guo, PP; Lin, CS Cardioprotective effect of novel sulphonamides-1,3,5-triazine conjugates against ischaemic-reperfusion injury via selective inhibition of MMP-9. Chem Biol Drug Des88:756-765 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 72 kDa type IV collagenase |
|---|
| Name: | 72 kDa type IV collagenase |
|---|
| Synonyms: | 72 kDa type IV collagenase | MMP2_RAT | Matrix metalloproteinase-2 (MMP-2) | Mmp2 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 74137.51 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P33436 |
|---|
| Residue: | 662 |
|---|
| Sequence: | MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGT
SYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGI
AQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGN
EYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKM
DPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWL
GC
|
|
|
|---|
| BDBM199128 |
|---|
| n/a |
|---|
| Name | BDBM199128 |
|---|
| Synonyms: | N-(4-(1-(4,6-dimorpholino-1,3,5-triazin-2-yl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)phenyl)-4-methylbenzenesulphonamide (8j) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H36N8O5S |
|---|
| Mol. Mass. | 668.765 |
|---|
| SMILES | COc1ccc(cc1)-c1cc(nn1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
