Reaction Details |
| Report a problem with these data |
Target | Tyrosine--tRNA ligase |
---|
Ligand | BDBM199142 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In vitro Enzyme Inhibition Assay |
---|
pH | 7.9±n/a |
---|
IC50 | 5.309e+4± 2.3e+2 nM |
---|
Comments | extracted |
---|
Citation | Chen, LW; Wang, PF; Tang, DJ; Tao, XX; Man, RJ; Qiu, HY; Wang, ZC; Xu, C; Zhu, HL Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation. Chem Biol Drug Des88:592-8 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine--tRNA ligase |
---|
Name: | Tyrosine--tRNA ligase |
Synonyms: | SYY_STAAS | Tyrosyl-tRNA synthetase | tyrS |
Type: | Protein |
Mol. Mass.: | 47586.43 |
Organism: | Staphylococcus aureus (strain MSSA476) |
Description: | n/a |
Residue: | 420 |
Sequence: | MTNVLIEDLKWRGLIYQQTDEQGIEDLLNKEQVTLYCGADPTADSLHIGHLLPFLTLRRF
QEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTEEQVDKNIEGISKQMHNIFEFGTDHGAV
LVNNRDWLGQISLISFLRDYGKHVGVNYMLGKDSIQSRLEHGISYTEFTYTILQAIDFGH
LNRELNCKIQVGGSDQWGNITSGIELMRRMYGQTDAYGLTIPLVTKSDGKKFGKSESGAV
WLDAEKTSPYEFYQFWINQSDEDVIKFLKYFTFLGKEEIDRLEQSKNEAPHLREAQKTLA
EEVTKFIHGEDALNDAIRISQALFSGDLKSLSAKELKDGFKDVPQVTLSNDTTNIVEVLI
ETGISPSKRQAREDVNNGAIYINGERQQDVNYALAPEDKIDGEFTIIRRGKKKYFMVNYQ
|
|
|
BDBM199142 |
---|
n/a |
---|
Name | BDBM199142 |
Synonyms: | 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)-ethyl-1,5-bis(4-chlorophenyl)-1H-pyrazole-3-carboxylate (4n) |
Type | Small organic molecule |
Emp. Form. | C22H17Cl2N5O4 |
Mol. Mass. | 486.307 |
SMILES | Cc1ncc(n1CCOC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)cc1)[N+]([O-])=O |
Structure |
|