| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM50443625 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Endothelial Lipase Assay |
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| pH | 7.2±n/a |
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| IC50 | 39±n/a nM |
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| Comments | extracted |
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| Citation |  Connelly, MA; Greco, M; Ye, H Tricyclic indole derivatives useful endothelial lipase inhibitors US Patent US9216998 Publication Date 12/22/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
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| Type: | Protein |
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| Mol. Mass.: | 56805.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5X9 |
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| Residue: | 500 |
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| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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|
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| BDBM50443625 |
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| n/a |
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| Name | BDBM50443625 |
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| Synonyms: | CHEMBL3092448 | US9216998, 25 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16F3NO |
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| Mol. Mass. | 331.3316 |
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| SMILES | FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23 |
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| Structure | 
|
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