| Reaction Details |
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 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase tankyrase-1 [1112-1317] |
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| Ligand | BDBM200002 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 1610±110 nM |
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| Comments | extracted |
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| Citation |  Cheung, AK; Chin, DN; Fan, J; Shultz, MD; Tomlinson, RC 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors US Patent US9227982 Publication Date 1/5/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Poly [ADP-ribose] polymerase tankyrase-1 [1112-1317] |
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| Name: | Poly [ADP-ribose] polymerase tankyrase-1 [1112-1317] |
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| Synonyms: | PARP5A | PARPL | TIN1 | TINF1 | TNKS | TNKS1 | TNKS1_HUMAN | Tankyrase 1 PARP catalytic domain (TNKS1P) |
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| Type: | n/a |
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| Mol. Mass.: | 23585.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O95271[1112-1317] |
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| Residue: | 206 |
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| Sequence: | APEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSE
ENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGG
TGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAE
YVIYRGEQAYPEYLITYQIMKPEAPS
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| BDBM200002 |
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| n/a |
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| Name | BDBM200002 |
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| Synonyms: | US9227982, 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22ClN3O3S |
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| Mol. Mass. | 443.946 |
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| SMILES | Clc1ccc(CN(Cc2nc3CCOCc3c(=O)[nH]2)C(=O)CCc2ccccc2)s1 |
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| Structure | 
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