| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Complement factor B |
|---|
| Ligand | BDBM160506 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Human Complement Factor B TR-FRET Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 55.0±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Adams, CM; Capparelli, MP; Ehara, T; Karki, RG; Mainolfi, N; Zhang, C Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof US Patent US10093663 Publication Date 10/9/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Complement factor B |
|---|
| Name: | Complement factor B |
|---|
| Synonyms: | BF | BFD | CFAB_HUMAN | CFB |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 85537.97 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00751 |
|---|
| Residue: | 764 |
|---|
| Sequence: | MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
|
|
|
|---|
| BDBM160506 |
|---|
| n/a |
|---|
| Name | BDBM160506 |
|---|
| Synonyms: | US10093663, Example 40 | US9682968, Example-40 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H31N3O3S |
|---|
| Mol. Mass. | 465.608 |
|---|
| SMILES | CC(=O)NS(=O)(=O)c1ccc(cc1)C1CCCCN1Cc1c(cc(C)c2[nH]ccc12)C1CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
