Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase SYK

Ligand

BDBM206177

Substrate/Competitor

n/a

Meas. Tech.

In vitro SYK Kinase Assay

7.2±n/a

Temperature

298.15±n/a K

IC50

806±n/a nM

Comments

extracted

Citation

Arora, N; Chen, S; Hermann, JC; Kuglstatter, A; Labadie, SS; Lin, CJ; Lucas, MC; Moore, AG; Papp, E; Talamas, FX; Wanner, J; Zhai, Y Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators US Patent US9255110 Publication Date 2/9/2016

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase SYK

Name:

Tyrosine-protein kinase SYK

Synonyms:

KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)

Type:

Enzyme

Mol. Mass.:

72079.99

Organism:

Homo sapiens (Human)

Description:

P43405

Residue:

635

Sequence:

MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN

BDBM206177

n/a

Name

BDBM206177

Synonyms:

US9255110, 90

Type

Small organic molecule

Emp. Form.

C19H19ClN4O3

Mol. Mass.

386.832

SMILES

OC1CCC(CC1)Oc1ccc(Cl)cc1NC(=O)c1cnn2cccnc12 |(5.33,-5,;4,-4.23,;2.67,-5,;1.33,-4.23,;1.33,-2.69,;2.67,-1.93,;4,-2.69,;,-1.93,;-1.33,-2.69,;-1.33,-4.23,;-2.67,-5,;-4,-4.23,;-5.33,-5,;-4,-2.69,;-2.67,-1.93,;-2.67,-.38,;-4,.38,;-5.33,-.38,;-4,1.93,;-5.33,2.69,;-5.33,4.23,;-2.67,4.23,;-1.33,5,;,4.23,;,2.69,;-1.33,1.93,;-2.67,2.69,)|

Structure