Ki Summary

Reaction Details

Report a problem with these data

Target

Tyrosine-protein kinase JAK2 [809-1153]

Ligand

BDBM185701

Substrate/Competitor

n/a

Meas. Tech.

JAK Enzymatic Assay

7.4±n/a

IC50

101±n/a nM

Comments

extracted

Citation

Mitton-Fry, MJ; Berlinski, PJ; Birchmeier, MJ; Bowman, JW; Gonzales, AJ; Kamerling, SG; Mann, DW Pyrrolo[2,3-D]pyrimidine compounds US Patent US9271981 Publication Date 3/1/2016

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK2 [809-1153]

Name:

Tyrosine-protein kinase JAK2 [809-1153]

Synonyms:

JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2

Type:

Protein

Mol. Mass.:

37870.86

Organism:

Homo sapiens (Human)

Description:

ThermoFisher Scientific, Cat no. PV4210 (809-1153 aa)

Residue:

324

Sequence:

FTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRY
DPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLI
MEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENEN
RVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELF
TYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNN
NVNQRPSFRDLALRVDQIRDNMAG

BDBM185701

n/a

Name

BDBM185701

Synonyms:

US9161939, 2 | US9271981, 2

Type

Small organic molecule

Emp. Form.

C18H27N5O2S

Mol. Mass.

377.504

SMILES

CN([C@H]1CC[C@H](CS(=O)(=O)NC2CCC2)CC1)c1ncnc2[nH]ccc12 |r,wU:2.1,wD:5.5,(-6.28,1.54,;-4.94,.77,;-3.61,1.54,;-3.61,3.08,;-2.28,3.85,;-.94,3.08,;.39,3.85,;1.72,3.08,;.95,1.75,;2.49,1.75,;3.06,3.85,;4.39,3.08,;4.79,1.59,;6.28,1.99,;5.88,3.48,;-.94,1.54,;-2.28,.77,;-4.94,-.77,;-6.28,-1.54,;-6.28,-3.08,;-4.94,-3.85,;-3.61,-3.08,;-2.28,-3.85,;-.94,-3.08,;-.94,-1.54,;-3.61,-1.54,)|

Structure