Reaction Details |
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Target | Carbonic anhydrase 2 [A65S,N67Q,E69T,I91L,F131V,K170E,L204A] |
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Ligand | BDBM10880 |
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Substrate/Competitor | n/a |
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Meas. Tech. | CA Inhibition Assay |
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Ki | 25±0.0 nM |
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Citation | Bhatt, A; Mahon, BP; Cruzeiro, VW; Cornelio, B; Laronze-Cochard, M; Ceruso, M; Sapi, J; Rance, GA; Khlobystov, AN; Fontana, A; Roitberg, A; Supuran, CT; McKenna, R Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity. Chembiochem18:213-222 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 2 [A65S,N67Q,E69T,I91L,F131V,K170E,L204A] |
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Name: | Carbonic anhydrase 2 [A65S,N67Q,E69T,I91L,F131V,K170E,L204A] |
Synonyms: | CA2 | CAH2_HUMAN | Carbonic anhydrase 9 (CA IX) |
Type: | Protein |
Mol. Mass.: | 29162.54 |
Organism: | Homo sapiens (Human) |
Description: | Chimeric protein of CA II with 7 mutations (A65S, N67Q, E69T, I91L, F131V, K170E, L204A); 5sZ4, 5SZ5, 5SZ6, 5SZ7 |
Residue: | 260 |
Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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BDBM10880 |
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n/a |
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Name | BDBM10880 |
Synonyms: | AZA | AZA2 | AZM acetazolamide | Acerazolamide, AAZ | Acetazolamide | Acetazolamide (AAZ) | Acetazolamide (AZA) | Acetazolamide (AZM) | Acetazolamide, 5 | Acetazolamide, AAZ | Acetazolamide, AZA | Acetazolamide, AZM | CHEMBL20 | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Sulfonamide, 1 | US10172837, Acetazolamide | US11278534, Example acetazolamide | US11535599, Example acetazolamide | sulfonamide 1 |
Type | Small organic molecule |
Emp. Form. | C4H6N4O3S2 |
Mol. Mass. | 222.245 |
SMILES | CC(=O)Nc1nnc(s1)S(N)(=O)=O |
Structure |
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