| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK [2-635] |
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| Ligand | BDBM50076185 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Chip Based Microfluidic Mobility Shift Assay |
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| pH | 7.5±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 23±n/a nM |
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| Comments | extracted |
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| Citation |  Smith, AB; Thoma, G; Van Eis, M Monocyclic heteroaryl cycloalkyldiamine derivatives US Patent US9290481 Publication Date 3/22/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase SYK [2-635] |
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| Name: | Tyrosine-protein kinase SYK [2-635] |
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| Synonyms: | KSYK_HUMAN | SYK | Tyrosine-protein kinase SYK | Tyrosine-protein kinase SYK (SYK) |
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| Type: | Protein |
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| Mol. Mass.: | 71948.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human Syk (2-635 aa) (UniProtKB: P43405) |
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| Residue: | 634 |
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| Sequence: | ASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKA
HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFE
DLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQI
VLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLV
EHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKP
GHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPK
EVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA
NVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMG
MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP
ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM
YDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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|
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| BDBM50076185 |
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| n/a |
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| Name | BDBM50076185 |
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| Synonyms: | CHEMBL3416026 | US9290481, 1.1 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N8O |
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| Mol. Mass. | 366.4203 |
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| SMILES | N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1 |r| |
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| Structure | 
|
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