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TargetGlycogen [starch] synthase, muscle
LigandBDBM212182
Substrate/Competitorn/a
Meas. Tech.Glycogen Synthase Activity Assay
pH7.3±n/a
Temperature303.15±n/a K
EC50 230±n/a nM
Commentsextracted
Citation Nakagawa, TMatsumoto, KTakeshita, SYoshida, TTokumasu, MInoue, HKobayashi, K Pharmaceutical composition for treating diabetes US Patent US9290487 Publication Date 3/22/2016
More Info.:Get all data from this article,  Assay Method
 
Glycogen [starch] synthase, muscle
Name:Glycogen [starch] synthase, muscle
Synonyms:GYS | GYS1 | GYS1_HUMAN | Glycogen [starch] synthase, muscle | Glycogen synthase (GYS1) | Muscle glycogen synthase
Type:Enzyme
Mol. Mass.:83779.52
Organism:Homo sapiens (Human)
Description:P13807
Residue:737
Sequence:
MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGD
NYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVG
ASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFH
EWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYH
RYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQS
KARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQ
TVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKML
DKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPE
FLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEE
HIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKY
LGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDE
EDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLS
TPSEPLSPTSSLGEERN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM212182
n/a
NameBDBM212182
Synonyms:US9290487, compound of Ex. 29
TypeSmall organic molecule
Emp. Form.C27H23FN2O4
Mol. Mass.458.4809
SMILESOC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2ccc(F)c3[nH]ccc23)c1 |r|
Structure
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