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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase SYK | ||
| Ligand | BDBM212267 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <0.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Altman, MD; Childers, KK; Di Francesco, ME; Ellis, JM; Fischer, C; Grimm, J; Haidle, AM; Kattar, SD; Northrup, AB; Otte, RD; Petrocchi, A; Schell, AJ; Zhou, H Aminopyrimidines as Syk inhibitors US Patent US9290490 Publication Date 3/22/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase SYK | |||
| Name: | Tyrosine-protein kinase SYK | ||
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72079.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P43405 | ||
| Residue: | 635 | ||
| Sequence: |
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| BDBM212267 | |||
| n/a | |||
| Name | BDBM212267 | ||
| Synonyms: | US9290490, Example 1 (faster eluting isomer) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25F3N4O3S | ||
| Mol. Mass. | 506.541 | ||
| SMILES | Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@@](C)(O)[C@H]1CC[C@@H](CC1)C(O)=O |wU:23.27,26.28,wD:29.35,23.25,(-.18,14.64,;1.16,13.87,;2.49,14.64,;3.82,13.87,;5.16,14.64,;5.16,16.18,;3.82,16.95,;3.82,18.49,;5.16,19.26,;6.49,18.49,;6.49,16.95,;7.82,19.26,;9.16,20.03,;8.59,17.93,;7.05,20.6,;3.82,12.33,;2.49,11.56,;1.16,12.33,;2.49,10.02,;1.24,9.12,;1.72,7.65,;3.26,7.65,;3.73,9.12,;4.16,6.41,;5.41,7.31,;2.92,5.5,;5.07,5.16,;6.6,5.32,;7.51,4.08,;6.88,2.67,;5.35,2.51,;4.44,3.75,;7.78,1.42,;9.32,1.58,;7.16,.02,)| | ||
| Structure | 
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