Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase SYK

Ligand

BDBM212229

Substrate/Competitor

n/a

Meas. Tech.

Homogeneous Time-Resolved Fluorescence (HTRF) Assay

7.5±n/a

Temperature

298.15±n/a K

IC50

<0.5±n/a nM

Comments

extracted

Citation

Altman, MD; Childers, KK; Di Francesco, ME; Ellis, JM; Fischer, C; Grimm, J; Haidle, AM; Kattar, SD; Northrup, AB; Otte, RD; Petrocchi, A; Schell, AJ; Zhou, H Aminopyrimidines as Syk inhibitors US Patent US9290490 Publication Date 3/22/2016

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase SYK

Name:

Tyrosine-protein kinase SYK

Synonyms:

KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)

Type:

Enzyme

Mol. Mass.:

72079.99

Organism:

Homo sapiens (Human)

Description:

P43405

Residue:

635

Sequence:

MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN

BDBM212229

n/a

Name

BDBM212229

Synonyms:

US9290490, 1-18

Type

Small organic molecule

Emp. Form.

C25H27FN4O3S

Mol. Mass.

482.57

SMILES

CC(O)(C1CCC(CC1)C(O)=O)c1ncc(s1)-c1cccc(Nc2ncc(F)c(n2)C2CC2)c1 |(.12,1.44,;.89,.11,;1.66,1.44,;2.43,.11,;3.2,-1.22,;4.74,-1.22,;5.57,.11,;4.74,1.44,;3.2,1.44,;7.11,.11,;7.88,1.44,;7.88,-1.22,;.12,-1.22,;-1.42,-1.22,;-1.9,-2.69,;-.65,-3.59,;.6,-2.69,;-.65,-5.13,;.68,-5.9,;.68,-7.44,;-.65,-8.21,;-1.98,-7.44,;-3.32,-8.21,;-4.65,-7.44,;-5.98,-8.21,;-7.32,-7.44,;-7.32,-5.9,;-8.81,-5.5,;-5.98,-5.13,;-4.65,-5.9,;-5.98,-3.59,;-7.32,-2.82,;-5.23,-2.82,;-1.98,-5.9,)|

Structure