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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase SYK | ||
| Ligand | BDBM212238 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <0.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Altman, MD; Childers, KK; Di Francesco, ME; Ellis, JM; Fischer, C; Grimm, J; Haidle, AM; Kattar, SD; Northrup, AB; Otte, RD; Petrocchi, A; Schell, AJ; Zhou, H Aminopyrimidines as Syk inhibitors US Patent US9290490 Publication Date 3/22/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase SYK | |||
| Name: | Tyrosine-protein kinase SYK | ||
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72079.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P43405 | ||
| Residue: | 635 | ||
| Sequence: |
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| BDBM212238 | |||
| n/a | |||
| Name | BDBM212238 | ||
| Synonyms: | US9290490, 2-77 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H32N4O3S | ||
| Mol. Mass. | 480.622 | ||
| SMILES | CC(C)c1ccnc(Nc2cc(C)cc(c2)-c2cnc(s2)C(C)(O)C2CCC(CC2)C(O)=O)n1 |(-5.09,-3.04,;-6.42,-3.81,;-7.51,-2.72,;-6.42,-5.35,;-7.76,-6.18,;-7.76,-7.72,;-6.42,-8.49,;-5.09,-7.72,;-3.76,-8.49,;-2.42,-7.72,;-1.09,-8.49,;.24,-7.72,;1.58,-8.49,;.24,-6.18,;-1.09,-5.41,;-2.42,-6.18,;-1.09,-3.87,;-2.34,-2.96,;-1.86,-1.5,;-.32,-1.5,;.16,-2.96,;.45,-.17,;1.22,1.17,;-.32,1.17,;1.99,-.17,;2.76,-1.5,;4.3,-1.5,;5.13,-.17,;4.3,1.17,;2.76,1.17,;6.67,-.17,;7.44,1.17,;7.44,-1.5,;-5.09,-6.18,)| | ||
| Structure | 
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