Reaction Details | |||
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Target | Tyrosine-protein kinase SYK | ||
Ligand | BDBM212258 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | <0.5±n/a nM | ||
Comments | extracted | ||
Citation | Altman, MD; Childers, KK; Di Francesco, ME; Ellis, JM; Fischer, C; Grimm, J; Haidle, AM; Kattar, SD; Northrup, AB; Otte, RD; Petrocchi, A; Schell, AJ; Zhou, H Aminopyrimidines as Syk inhibitors US Patent US9290490 Publication Date 3/22/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase SYK | |||
Name: | Tyrosine-protein kinase SYK | ||
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
Type: | Enzyme | ||
Mol. Mass.: | 72079.99 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P43405 | ||
Residue: | 635 | ||
Sequence: |
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BDBM212258 | |||
n/a | |||
Name | BDBM212258 | ||
Synonyms: | US9290490, Example 15 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H25F3N4O4S | ||
Mol. Mass. | 522.54 | ||
SMILES | C[C@@](O)([C@H]1CC[C@@H](CC1)C(O)=O)c1ncc(s1)-c1cc(CO)cc(Nc2nccc(n2)C(F)(F)F)c1 |r,wU:1.1,6.9,wD:1.12,3.8,(-.42,-5.66,;.83,-4.75,;2.07,-3.85,;1.73,-6,;1.11,-7.4,;2.01,-8.65,;3.54,-8.49,;4.17,-7.08,;3.27,-5.84,;4.45,-9.73,;5.98,-9.57,;3.82,-11.14,;-.08,-3.5,;-1.62,-3.5,;-2.09,-2.04,;-.85,-1.13,;.4,-2.04,;-.85,.41,;.49,1.18,;.49,2.72,;1.82,3.49,;3.15,2.72,;-.85,3.49,;-2.18,2.72,;-3.51,3.49,;-3.51,5.03,;-2.18,5.8,;-2.18,7.34,;-3.51,8.11,;-4.85,7.34,;-4.85,5.8,;-6.18,8.11,;-7.51,8.88,;-5.41,9.44,;-6.95,6.77,;-2.18,1.18,)| | ||
Structure |