Reaction Details | |||
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Target | Tyrosine-protein kinase SYK | ||
Ligand | BDBM212261 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | <0.5±n/a nM | ||
Comments | extracted | ||
Citation | Altman, MD; Childers, KK; Di Francesco, ME; Ellis, JM; Fischer, C; Grimm, J; Haidle, AM; Kattar, SD; Northrup, AB; Otte, RD; Petrocchi, A; Schell, AJ; Zhou, H Aminopyrimidines as Syk inhibitors US Patent US9290490 Publication Date 3/22/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase SYK | |||
Name: | Tyrosine-protein kinase SYK | ||
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
Type: | Enzyme | ||
Mol. Mass.: | 72079.99 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P43405 | ||
Residue: | 635 | ||
Sequence: |
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BDBM212261 | |||
n/a | |||
Name | BDBM212261 | ||
Synonyms: | US9290490, Example 18 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H23F5N4O3S | ||
Mol. Mass. | 542.521 | ||
SMILES | CC(O)([C@H]1CC[C@@H](CC1)C(O)=O)c1ncc(s1)-c1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)C(F)F |r,wU:6.9,wD:3.2,(4.78,1.69,;3.3,1.29,;4.38,.2,;2.9,2.78,;3.99,3.87,;3.59,5.35,;2.1,5.75,;1.01,4.66,;1.41,3.18,;1.7,7.24,;2.79,8.33,;.21,7.64,;2.21,.2,;.67,.2,;.19,-1.26,;1.44,-2.17,;2.68,-1.26,;1.44,-3.71,;.1,-4.48,;.1,-6.02,;-1.23,-6.79,;-2.56,-6.02,;-3.9,-6.79,;-5.23,-6.02,;-5.23,-4.48,;-3.9,-3.65,;-2.56,-4.48,;-3.9,-2.11,;-3.9,-.57,;-2.36,-2.11,;-5.44,-2.11,;1.44,-6.79,;2.77,-6.02,;2.77,-4.48,;4.1,-6.79,;5.44,-6.02,;4.1,-8.33,)| | ||
Structure |