Reaction Details |
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Target | ATP-sensitive inward rectifier potassium channel 1 |
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Ligand | BDBM290099 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Electrophysiology Assay |
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pH | 7.4±n/a |
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IC50 | 400±n/a nM |
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Comments | extracted |
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Citation | Pasternak, A; DeJesus, RK; Frie, JL; Pio, B; Tang, H; Walsh, SP Inhibitors of the renal outer medullary potassium channel US Patent US9573961 Publication Date 2/21/2017 |
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More Info.: | Get all data from this article, Assay Method |
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ATP-sensitive inward rectifier potassium channel 1 |
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Name: | ATP-sensitive inward rectifier potassium channel 1 |
Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44809.08 |
Organism: | Homo sapiens (Human) |
Description: | gi_223460826 |
Residue: | 391 |
Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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BDBM290099 |
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n/a |
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Name | BDBM290099 |
Synonyms: | US9573961, Example 84 | US9573961, Example 85 |
Type | Small organic molecule |
Emp. Form. | C28H30N6O4 |
Mol. Mass. | 514.5756 |
SMILES | C[C@@H]1Cc2cc(ccc2C(=O)O1)[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)C1CCc2cc(ccc12)-n1cnnn1 |r| |
Structure |
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