| Reaction Details |
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 | Report a problem with these data |
| Target | Adenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686] |
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| Ligand | BDBM50094484 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AlphaScreen Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 8310±1050 nM |
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| Comments | extracted |
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| Citation |  Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent US9284299 Publication Date 3/15/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Adenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686] |
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| Name: | Adenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686] |
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| Synonyms: | Beta-catenin/APC-R3 |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Catenin beta-1 [138-686] |
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| Synonyms: | Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1 |
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| Type: | Protein |
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| Mol. Mass.: | 60127.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 138-686 |
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| Residue: | 549 |
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| Sequence: | NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSA
IVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAIT
TLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILA
SGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRL
VQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMM
VCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKL
LHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQ
QQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGV
LCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVE
LTSSLFRTE
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| Component 2 |
| Name: | Adenomatous polyposis coli protein [1477-1519] |
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| Synonyms: | APC | APC_HUMAN | Adenomatous polyposis coli protein (APC-R3) | DP2.5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 4662.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human APC-R3 truncation (1477-1519 aa) |
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| Residue: | 43 |
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| Sequence: | QRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDEPFIQKD
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| BDBM50094484 |
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| n/a |
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| Name | BDBM50094484 |
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| Synonyms: | CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 | US9738628, Compound CGP049090 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H26O10 |
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| Mol. Mass. | 534.5107 |
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| SMILES | COc1c(C[C@H](C)O)c2c3c(C[C@H](C)O)c(OC)c(=O)c4c(O)cc5OCOc6cc(O)c(c2c6c5c34)c1=O |r| |
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| Structure | 
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