Reaction Details |
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Target | Adenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686] |
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Ligand | BDBM32102 |
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Substrate/Competitor | n/a |
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Meas. Tech. | AlphaScreen Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Ki | 66230±3390 nM |
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Comments | extracted |
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Citation | Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent US9284299 Publication Date 3/15/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Adenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686] |
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Name: | Adenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686] |
Synonyms: | Beta-catenin/APC-R3 |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Catenin beta-1 [138-686] |
Synonyms: | Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1 |
Type: | Protein |
Mol. Mass.: | 60127.24 |
Organism: | Homo sapiens (Human) |
Description: | aa 138-686 |
Residue: | 549 |
Sequence: | NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSA
IVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAIT
TLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILA
SGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRL
VQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMM
VCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKL
LHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQ
QQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGV
LCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVE
LTSSLFRTE
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Component 2 |
Name: | Adenomatous polyposis coli protein [1477-1519] |
Synonyms: | APC | APC_HUMAN | Adenomatous polyposis coli protein (APC-R3) | DP2.5 |
Type: | Enzyme |
Mol. Mass.: | 4662.54 |
Organism: | Homo sapiens (Human) |
Description: | Human APC-R3 truncation (1477-1519 aa) |
Residue: | 43 |
Sequence: | QRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDEPFIQKD
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BDBM32102 |
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n/a |
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Name | BDBM32102 |
Synonyms: | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone | MLS000087831 | SMR000024051 | US9284299, PKF118-310 | US9738628, Compound PKF118-310 | cid_66541 |
Type | Small organic molecule |
Emp. Form. | C7H7N5O2 |
Mol. Mass. | 193.1628 |
SMILES | Cn1ncnc2c1nc(=O)n(C)c2=O |
Structure |
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