| Reaction Details |
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 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter [P314T] |
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| Ligand | BDBM50017712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | [3H]Serotonin Uptake Assay |
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| pH | 8.5±n/a |
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| IC50 | 4.3±0.1 nM |
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| Comments | extracted |
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| Citation |  Ugolev, Y; Segal, T; Yaffe, D; Gros, Y; Schuldiner, S Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine. J Biol Chem288:32160-71 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Synaptic vesicular amine transporter [P314T] |
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| Name: | Synaptic vesicular amine transporter [P314T] |
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| Synonyms: | Slc18a2 | Svat | VMAT2_RAT | Vesicular monoamine transporter 2 (VMAT P314T) | Vmat2 |
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| Type: | Protein |
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| Mol. Mass.: | 55693.57 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Rat VMAT2 P314T mutant |
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| Residue: | 515 |
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| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLETALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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| BDBM50017712 |
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| n/a |
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| Name | BDBM50017712 |
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| Synonyms: | (-)-reserpine | (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester | 3,4,5-trimethoxybenzoyl methyl reserpate | Apoplon | CHEMBL772 | NCGC00091250 | RESERPINE | Reserpin | Serpalan | cid_5770 | methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C33H40N2O9 |
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| Mol. Mass. | 608.6787 |
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| SMILES | CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c1cc(OC)c(OC)c(OC)c1 |r| |
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| Structure | 
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