| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
|---|
| Ligand | BDBM50327851 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescent Based Assay |
|---|
| pH | 7±n/a |
|---|
| IC50 | 1.2±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Hammock, BD; Rose, T; Morisseau, C; Lee, KS Acyl piperidine inhibitors of soluble epoxide hydrolase US Patent US9296693 Publication Date 3/29/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional epoxide hydrolase 2 |
|---|
| Name: | Bifunctional epoxide hydrolase 2 |
|---|
| Synonyms: | Eph2 | Ephx2 | Epoxide hydratase | HYES_MOUSE | Soluble epoxide hydrolase (sEH) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 62512.06 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | P34914 |
|---|
| Residue: | 554 |
|---|
| Sequence: | MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITF
SQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTC
IVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYV
TVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPF
MPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHK
ATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLG
RKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKW
LQTEVQNPSVTSKI
|
|
|
|---|
| BDBM50327851 |
|---|
| n/a |
|---|
| Name | BDBM50327851 |
|---|
| Synonyms: | 1-(1-((4-Acetylpiperazin-1-yl)acetyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea | CHEMBL1257404 | US9296693, 51 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H28F3N5O4 |
|---|
| Mol. Mass. | 471.4733 |
|---|
| SMILES | CC(=O)N1CCN(CC(=O)N2CCC(CC2)NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
