| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-oxoacyl-[acyl-carrier-protein] synthase 1 |
|---|
| Ligand | BDBM214777 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Kinetics Assay |
|---|
| pH | 8.5±n/a |
|---|
| Kd | 1.120e+5± 3.0e+3 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Schiebel, J; Kapilashrami, K; Fekete, A; Bommineni, GR; Schaefer, CM; Mueller, MJ; Tonge, PJ; Kisker, C Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis. J Biol Chem288:34190-204 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-oxoacyl-[acyl-carrier-protein] synthase 1 |
|---|
| Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 1 |
|---|
| Synonyms: | β-ketoacyl-ACP synthase I (KasA) | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | Beta-ketoacyl-ACP synthase (KasA) | KASA_MYCTU | kasA |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43305.57 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | P9WQD9 |
|---|
| Residue: | 416 |
|---|
| Sequence: | MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKI
GGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAE
RIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGARAGVMTPVSACSSGSEAIAH
AWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGL
SPADIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVL
TLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNSFGFGGHNVALAFGRY
|
|
|
|---|
| BDBM214777 |
|---|
| n/a |
|---|
| Name | BDBM214777 |
|---|
| Synonyms: | TLM18 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H19N3O2S |
|---|
| Mol. Mass. | 293.385 |
|---|
| SMILES | C\C(C=C)=C/[C@@]1(C)SC(=O)C(CCCCN=[N+]=[N-])=C1O |r,c:17| |
|---|
| Structure | 
|
|---|
Search and Browse
