| Reaction Details |
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 | Report a problem with these data |
| Target | Uridine 5'-monophosphate synthase |
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| Ligand | BDBM214780 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 530±200 nM |
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| Comments | extracted |
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| Citation |  Zhang, Y; Evans, GB; Clinch, K; Crump, DR; Harris, LD; Fröhlich, RF; Tyler, PC; Hazleton, KZ; Cassera, MB; Schramm, VL Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Biol Chem288:34746-54 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Uridine 5'-monophosphate synthase |
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| Name: | Uridine 5'-monophosphate synthase |
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| Synonyms: | Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 52224.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11172 |
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| Residue: | 480 |
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| Sequence: | MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
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| BDBM214780 |
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| n/a |
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| Name | BDBM214780 |
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| Synonyms: | OPRT inhibitor, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H15BrN3O5 |
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| Mol. Mass. | 337.147 |
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| SMILES | OC[C@H]1[NH2+][C@@H](Cn2cc(Br)c(=O)[nH]c2=O)C(O)C1O |r| |
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| Structure | 
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