| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Uridine 5'-monophosphate synthase |
|---|
| Ligand | BDBM214790 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 8±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | 250±90 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Zhang, Y; Evans, GB; Clinch, K; Crump, DR; Harris, LD; Fröhlich, RF; Tyler, PC; Hazleton, KZ; Cassera, MB; Schramm, VL Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Biol Chem288:34746-54 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Uridine 5'-monophosphate synthase |
|---|
| Name: | Uridine 5'-monophosphate synthase |
|---|
| Synonyms: | Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52224.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11172 |
|---|
| Residue: | 480 |
|---|
| Sequence: | MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
|
|
|
|---|
| BDBM214790 |
|---|
| n/a |
|---|
| Name | BDBM214790 |
|---|
| Synonyms: | OPRT inhibitor, 13 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H14N3O4 |
|---|
| Mol. Mass. | 240.2353 |
|---|
| SMILES | OC(=O)c1[nH]c(=O)[nH]c(=O)c1C[NH+]1CCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
