Reaction Details |
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Target | Uridine 5'-monophosphate synthase |
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Ligand | BDBM214793 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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pH | 8±n/a |
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Temperature | 298.15±n/a K |
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Ki | 230±90 nM |
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Comments | extracted |
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Citation | Zhang, Y; Evans, GB; Clinch, K; Crump, DR; Harris, LD; Fröhlich, RF; Tyler, PC; Hazleton, KZ; Cassera, MB; Schramm, VL Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Biol Chem288:34746-54 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Uridine 5'-monophosphate synthase |
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Name: | Uridine 5'-monophosphate synthase |
Synonyms: | Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 52224.99 |
Organism: | Homo sapiens (Human) |
Description: | P11172 |
Residue: | 480 |
Sequence: | MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
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BDBM214793 |
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n/a |
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Name | BDBM214793 |
Synonyms: | OPRT inhibitor, 16 |
Type | Small organic molecule |
Emp. Form. | C11H15N2O5 |
Mol. Mass. | 255.2467 |
SMILES | OC[C@H]1[NH2+][C@H](C(O)C1O)c1ccc(cc1)[N+]([O-])=O |r| |
Structure |
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