| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase ITK/TSK |
|---|
| Ligand | BDBM290229 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Activity Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 5.00±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Brameld, KA; Owens, T Benzimidazole derivatives as ITK inhibitors US Patent US9573958 Publication Date 2/21/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase ITK/TSK |
|---|
| Name: | Tyrosine-protein kinase ITK/TSK |
|---|
| Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 71839.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q08881 |
|---|
| Residue: | 620 |
|---|
| Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
|
|
|
|---|
| BDBM290229 |
|---|
| n/a |
|---|
| Name | BDBM290229 |
|---|
| Synonyms: | US9573958, Compound 60 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H40F2N6O2S |
|---|
| Mol. Mass. | 610.761 |
|---|
| SMILES | CC(C)C=C(C#N)C(=O)N1CCC[C@@H]1Cn1c(NC(=O)c2ccc(s2)C(F)F)nc2cc(CN[C@@H](C)C(C)(C)C)ccc12 |w:3.2| |
|---|
| Structure | 
|
|---|
Search and Browse
