| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
|---|
| Ligand | BDBM217087 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Binding Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | 257±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Curtin, ML; Sorensen, BK; Heyman, HR; Clark, RF; Woller, KR; Shah, OJ; Michaelides, M; Tse, C; Vasudevan, A; Mack, H; Hansen, TM; Sweis, R; Pliushchev, MA NAMPT and rock inhibitors US Patent US9302989 Publication Date 4/5/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nicotinamide phosphoribosyltransferase |
|---|
| Name: | Nicotinamide phosphoribosyltransferase |
|---|
| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55524.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43490 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
|
|
|
|---|
| BDBM217087 |
|---|
| n/a |
|---|
| Name | BDBM217087 |
|---|
| Synonyms: | US9302989, 382 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H21N3O3 |
|---|
| Mol. Mass. | 411.4525 |
|---|
| SMILES | COc1ccc2CN(Cc2c1)C(=O)Nc1ccc(cc1)-c1c[nH]c(=O)c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
