| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM218174 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC Activity Assay |
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| pH | 8±n/a |
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| IC50 | 174±n/a nM |
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| Comments | extracted |
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| Citation |  Kozikowski, A; Kalin, JH; Butler, KV; Bergman, J; Hancock, WW HDAC inhibitors and therapeutic methods using the same US Patent US9249087 Publication Date 2/2/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM218174 |
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| n/a |
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| Name | BDBM218174 |
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| Synonyms: | US9249087, 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N4O2 |
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| Mol. Mass. | 394.5099 |
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| SMILES | CN1CCN(CCc2cn(CC3=CCC(C=C3)C(=O)NO)c3ccccc23)CC1 |c:15,t:11| |
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| Structure | 
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