Reaction Details |
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Target | Bromodomain-containing protein 4 [57-168] |
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Ligand | BDBM220516 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Bromodomain Domain Binding Assay |
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pH | 6±n/a |
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Temperature | 298.15±n/a K |
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Ki | 0.52±n/a nM |
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Comments | extracted |
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Citation | Wang, L; Pratt, JK; McDaniel, KF; Dai, Y; Fidanze, SD; Hasvold, L; Holms, JH; Kati, WM; Liu, D; Mantei, RA; McClellan, WJ; Sheppard, GS; Wada, CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Bromodomain-containing protein 4 [57-168] |
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Name: | Bromodomain-containing protein 4 [57-168] |
Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 57-168) | Bromodomain-containing protein 4 (BRD4-BD1) | HUNK1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 13496.03 |
Organism: | Homo sapiens (Human) |
Description: | BDI: amino acids K57-E168 |
Residue: | 112 |
Sequence: | KRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLEN
NYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
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BDBM220516 |
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n/a |
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Name | BDBM220516 |
Synonyms: | US9296741, 105 |
Type | Small organic molecule |
Emp. Form. | C21H25N3O5S |
Mol. Mass. | 431.505 |
SMILES | CCS(=O)(=O)Nc1ccc(OC2CCCOC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12 |
Structure |
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