| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Membrane primary amine oxidase |
|---|
| Ligand | BDBM220876 |
|---|
| Substrate/Competitor | US9302986, benzylamine |
|---|
| Meas. Tech. | Recombinant SSAO/VAP-1 Inhibition Assay in Rat Fat |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | <100000±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Deodhar, M; Findlay, AD; Foot, JS; Jarolimek, W; Mcdonald, IA; Robertson, AD; Turner, CI Substituted 3-haloallylamine inhibitors of ASSAO and uses thereof US Patent US9302986 Publication Date 4/5/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Membrane primary amine oxidase |
|---|
| Name: | Membrane primary amine oxidase |
|---|
| Synonyms: | AOC3_RAT | Amine oxidase, copper containing | Aoc3 | Semicarbazide-sensitive amine oxidase/ Vascular adhesion protein 1 (SSAO/VAP-1) | Vascular adhesion protein 1 (VAP-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 84979.78 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | O08590 |
|---|
| Residue: | 763 |
|---|
| Sequence: | MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPF
ADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPP
VREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQ
EMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYP
HPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSW
SLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVA
YEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQ
TPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFH
SNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAW
AEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHR
RGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDF
TDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSP
DSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK
|
|
|
|---|
| BDBM220876 |
|---|
| US9302986, benzylamine |
|---|
| Name | BDBM220876 |
|---|
| Synonyms: | US9302986, 15 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H17FN2O3S |
|---|
| Mol. Mass. | 288.338 |
|---|
| SMILES | CN(C)S(=O)(=O)c1cccc(OC\C(CN)=C/F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
