| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM221345 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 225±n/a nM |
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| Comments | extracted |
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| Citation |  Bolli, M; Boss, C; Brotschi, C; Gude, M; Heidmann, B; Sifferlen, T; Williams, JT Pyrazole and imidazole derivatives useful as orexin antagonists US Patent US9303023 Publication Date 4/5/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM221345 |
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| n/a |
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| Name | BDBM221345 |
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| Synonyms: | US9303023, 44 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25N5O2S |
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| Mol. Mass. | 471.574 |
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| SMILES | COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncsc4-c4ccc(C)c(C)c4)cn3)c2c1 |
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| Structure | 
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