| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 3A |
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| Ligand | BDBM221561 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibition of Ca Flux Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 0.33±n/a nM |
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| Comments | extracted |
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| Citation |  Hitchcock, S; Monenschein, H; Reichard, H; Sun, H; Kikuchi, S; Macklin, T; Hopkins, M 5-HT3 receptor antagonists US Patent US9303045 Publication Date 4/5/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 3A |
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| Name: | 5-hydroxytryptamine receptor 3A |
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| Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 |
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| Type: | Protein |
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| Mol. Mass.: | 55283.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46098 |
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| Residue: | 478 |
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| Sequence: | MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT
VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI
LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR
RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI
GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ
STSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ
ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
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|
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| BDBM221561 |
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| n/a |
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| Name | BDBM221561 |
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| Synonyms: | US9303045, 47 | US9695195, 47 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N2O5S |
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| Mol. Mass. | 378.443 |
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| SMILES | CN1C2COCC1CC(C2)OC(=O)c1cn(c2ccccc12)S(C)(=O)=O |THB:10:8:1:3.5.4| |
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| Structure | 
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