Reaction Details |
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Target | Chymotrypsinogen A |
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Ligand | BDBM50289012 |
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Substrate/Competitor | n/a |
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Meas. Tech. | α-Chymotrypsin Inhibition Assay |
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pH | 7.6±n/a |
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IC50 | 6.5e+3± 2e+2 nM |
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Comments | extracted |
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Citation | Marasini, BP; Rahim, F; Perveen, S; Karim, A; Mohammed Khan, K; Atta-Ur-Rahman, null; Choudhary, MI Synthesis, structure-activity relationships studies of benzoxazinone derivatives as a-chymotrypsin inhibitors. Bioorg Chem70:210-221 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Chymotrypsinogen A |
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Name: | Chymotrypsinogen A |
Synonyms: | Alpha-chymotrypsin | CTRA_BOVIN | Chymotrypsin A | Chymotrypsin A chain A | Chymotrypsin A chain B | Chymotrypsin A chain C | Chymotrypsinogen A | alpha-Chymotrypsin (α-Chymotrypsin) |
Type: | Serine protease |
Mol. Mass.: | 25670.88 |
Organism: | Bos taurus (bovine) |
Description: | n/a |
Residue: | 245 |
Sequence: | CGVPAIQPVLSGLSRIVNGEEAVPGSWPWQVSLQDKTGFHFCGGSLINENWVVTAAHCGV
TTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYNSLTINNDITLLKLSTAASFSQTVSA
VCLPSASDDFAAGTTCVTTGWGLTRYTNANTPDRLQQASLPLLSNTNCKKYWGTKIKDAM
ICAGASGVSSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQ
TLAAN
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BDBM50289012 |
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n/a |
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Name | BDBM50289012 |
Synonyms: | 2-(2-Fluoro-phenyl)-benzo[d][1,3]oxazin-4-one | 2-(2-Fluorophenyl)-4H-3,1-benzoxazin-4-one (1) | CHEMBL161656 |
Type | Small organic molecule |
Emp. Form. | C14H8FNO2 |
Mol. Mass. | 241.2172 |
SMILES | Fc1ccccc1-c1nc2ccccc2c(=O)o1 |
Structure |
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