| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Ligand | BDBM222183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Alkaline Phosphatase Inhibition Assay |
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| pH | 9.8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 6.63e+3± 6.0e+2 nM |
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| Comments | extracted |
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| Citation |  Bhatti, HA; Khatoon, M; Al-Rashida, M; Bano, H; Iqbal, N; Zaib-Un-Nisa, null; Yousuf, S; Khan, KM; Hameed, A; Iqbal, J Facile dimethyl amino group triggered cyclic sulfonamides synthesis and evaluation as alkaline phosphatase inhibitors. Bioorg Chem71:10-18 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alkaline phosphatase, tissue-nonspecific isozyme |
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| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Synonyms: | ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP) |
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| Type: | Protein |
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| Mol. Mass.: | 57195.60 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P09487 |
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| Residue: | 524 |
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| Sequence: | MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDE
KARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELN
RNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIG
QAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYI
PHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
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| BDBM222183 |
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| n/a |
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| Name | BDBM222183 |
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| Synonyms: | 6-(Dimethylamino)-3-(4'-thiomethylphenyl)-2,3-dihydronaphtho[1,8-de][1,2]thiazine 1,1-dioxide (7e) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N2O2S2 |
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| Mol. Mass. | 384.515 |
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| SMILES | CSc1ccc(cc1)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C |
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| Structure | 
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