| Reaction Details |
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 | Report a problem with these data |
| Target | Intestinal-type alkaline phosphatase |
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| Ligand | BDBM222179 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Alkaline Phosphatase Inhibition Assay |
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| pH | 9.8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 1.12e+3± 2e+1 nM |
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| Comments | extracted |
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| Citation |  Bhatti, HA; Khatoon, M; Al-Rashida, M; Bano, H; Iqbal, N; Zaib-Un-Nisa, null; Yousuf, S; Khan, KM; Hameed, A; Iqbal, J Facile dimethyl amino group triggered cyclic sulfonamides synthesis and evaluation as alkaline phosphatase inhibitors. Bioorg Chem71:10-18 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Intestinal-type alkaline phosphatase |
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| Name: | Intestinal-type alkaline phosphatase |
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| Synonyms: | ALPI | Intestinal alkaline phosphatase | Intestinal alkaline phosphatase (IAP) | Intestinal-type alkaline phosphatase (IAP) | PPBI_BOVIN |
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| Type: | Protein |
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| Mol. Mass.: | 57094.82 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P19111 |
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| Residue: | 533 |
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| Sequence: | MQGACVLLLLGLHLQLSLGLVPVEEEDPAFWNRQAAQALDVAKKLQPIQTAAKNVILFLG
DGMGVPTVTATRILKGQMNGKLGPETPLAMDQFPYVALSKTYNVDRQVPDSAGTATAYLC
GVKGNYRTIGVSAAARYNQCKTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADLPADAQMNGCQDIAAQLVNNMDIDVILGGGRKYMFPVGTPDPEYPDDA
SVNGVRKRKQNLVQAWQAKHQGAQYVWNRTALLQAADDSSVTHLMGLFEPADMKYNVQQD
HTKDPTLQEMTEVALRVVSRNPRGFYLFVEGGRIDHGHHDDKAYMALTEAGMFDNAIAKA
NELTSELDTLILVTADHSHVFSFGGYTLRGTSIFGLAPSKALDSKSYTSILYGNGPGYAL
GGGSRPDVNDSTSEDPSYQQQAAVPQASETHGGEDVAVFARGPQAHLVHGVEEETFVAHI
MAFAGCVEPYTDCNLPAPTTATSIPDAAHLAASPPPLALLAGAMLLLLAPTLY
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| BDBM222179 |
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| n/a |
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| Name | BDBM222179 |
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| Synonyms: | 6-(Dimethylamino)-3-phenyl-2,3-dihydronaphtho[1,8-de][1,2]thiazine 1,1-dioxide (7a) |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18N2O2S |
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| Mol. Mass. | 338.423 |
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| SMILES | CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccccc1 |
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| Structure | 
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