Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTyrosine-protein kinase ABL1 [64-515]
LigandBDBM222491
Substrate/Competitorn/a
Meas. Tech.Radiometric Filter-Binding Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 31±n/a nM
Commentsextracted
Citation Furet, PGrotzfeld, RMJahnke, WJones, DBManley, PWMarzinzik, AMoussaoui, SPelle, XFSalem, BSchoepfer, J Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent US9315489 Publication Date 4/19/2016
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase ABL1 [64-515]
Name:Tyrosine-protein kinase ABL1 [64-515]
Synonyms:ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1)
Type:Enzyme Catalytic Domain
Mol. Mass.:51539.77
Organism:Homo sapiens (Human)
Description:aa 64-515
Residue:452
Sequence:
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM222491
n/a
NameBDBM222491
Synonyms:US9315489, 27
TypeSmall organic molecule
Emp. Form.C19H12ClF3N2O2
Mol. Mass.392.759
SMILESFC(F)(F)Oc1ccc(NC(=O)c2ccc(Cl)c(c2)-c2ccncc2)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: