Reaction Details |
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Target | Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 |
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Ligand | BDBM222972 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence Laser Imaging Plate Reader (FLIPR) Based Assay |
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EC50 | 16.02±n/a nM |
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Citation | Fiji, HD; Kelly, III, MJ; Kern, JC; Layton, ME; Pero, JE; Reif, AJ; Rossi, MA Imidazopyridin-2-one derivatives US Patent US9315518 Publication Date 4/19/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 |
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Name: | Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 |
Synonyms: | Guanine nucleotide-binding protein subunit alpha-15/Metabotropic glutamate receptor 2 | mGluR2 and G alpha 16 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Metabotropic glutamate receptor 2 |
Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 |
Type: | Enzyme |
Mol. Mass.: | 95584.88 |
Organism: | Homo sapiens (Human) |
Description: | Q14416 |
Residue: | 872 |
Sequence: | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
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Component 2 |
Name: | Guanine nucleotide-binding protein subunit alpha-15 |
Synonyms: | G protein alpha 16 | G-protein subunit alpha-16 | G-protein subunit alpha-16 (G alpha-16) | GNA15 | GNA15_HUMAN | GNA16 | Guanine nucleotide-binding protein subunit alpha-15 [Y147C] |
Type: | Protein |
Mol. Mass.: | 43577.62 |
Organism: | Homo sapiens (Human) |
Description: | P30679 |
Residue: | 374 |
Sequence: | MARSLTWRCCPWCLTEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIK
QMRIIHGAGYSEEERKGFRPLVYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLVMSQD
PYKVTTFEKRYAAAMQWLWRDAGIRACYERRREFHLLDSAVYYLSHLERITEEGYVPTAQ
DVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQ
CLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFQG
PKQDAEAAKRFILDMYTRMYTGCVDGPEGSKKGARSRRLFSHYTCATDTQNIRKVFKDVR
DSVLARYLDEINLL
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BDBM222972 |
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n/a |
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Name | BDBM222972 |
Synonyms: | US9315518, 2-7 | US9315518, 5-2 |
Type | Small organic molecule |
Emp. Form. | C23H27N5O3 |
Mol. Mass. | 421.4922 |
SMILES | Cn1c2nc(ccc2n(CC(C)(C)C)c1=O)C1=CC2CCC1CN2C(=O)c1ccon1 |t:18| |
Structure |
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