| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM223018 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| pH | 6.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | <750±n/a nM |
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| Comments | extracted |
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| Citation |  Combs, AP; Yue, EW; Sparks, RB; Zhu, W 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase US Patent US9320732 Publication Date 4/26/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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|
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| BDBM223018 |
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| n/a |
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| Name | BDBM223018 |
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| Synonyms: | US10034939, Example 20 | US10967060, Example 20 | US11207302, Example 20 | US9320732, 20 | US9320732, 21 | US9789094, 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14BrN7O5S |
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| Mol. Mass. | 424.231 |
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| SMILES | NS(=O)(=O)NCCNc1nonc1C(NCc1cc(Br)co1)=NO |w:22.24| |
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| Structure | 
|
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