Reaction Details |
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Target | Protein arginine N-methyltransferase 1 [11-371] |
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Ligand | BDBM223137 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Enzymatic Assay |
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Temperature | 298.15±n/a K |
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IC50 | >1.00e+5±n/a nM |
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Comments | extracted |
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Citation | Ji, S; Ma, S; Wang, WJ; Huang, SZ; Wang, TQ; Xiang, R; Hu, YG; Chen, Q; Li, LL; Yang, SY Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations. Chem Biol Drug Des89:585-598 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein arginine N-methyltransferase 1 [11-371] |
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Name: | Protein arginine N-methyltransferase 1 [11-371] |
Synonyms: | ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1 |
Type: | Protein |
Mol. Mass.: | 41506.52 |
Organism: | Homo sapiens (Human) |
Description: | Q99873[11-371] |
Residue: | 361 |
Sequence: | MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
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BDBM223137 |
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n/a |
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Name | BDBM223137 |
Synonyms: | P5i-6 |
Type | Small organic molecule |
Emp. Form. | C12H10ClN3O2 |
Mol. Mass. | 263.68 |
SMILES | NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1 |
Structure |
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