Ki Summary

Reaction Details

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Target

Oplophorus-luciferin 2-monooxygenase catalytic subunit

Ligand

BDBM223160

Substrate/Competitor

n/a

Meas. Tech.

NanoLuc Inhibition Assay

IC50

3.9±n/a nM

Citation

Walker, JR; Hall, MP; Zimprich, CA; Robers, MB; Duellman, SJ; Machleidt, T; Rodriguez, J; Zhou, W Highly Potent Cell-Permeable and Impermeable NanoLuc Luciferase Inhibitors. ACS Chem Biol12:1028-1037 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Oplophorus-luciferin 2-monooxygenase catalytic subunit

Name:

Oplophorus-luciferin 2-monooxygenase catalytic subunit

Synonyms:

19kOLase (EC:1.13.12.13) | LUCI_OPLGR | NanoLuc luciferase (Nluc)

Type:

Enzyme

Mol. Mass.:

21528.45

Organism:

Oplophorus gracilirostris (Luminous shrimp)

Description:

Q9GV45

Residue:

196

Sequence:

MAYSTLFIIALTAVVTQASSTQKSNLTFTLADFVGDWQQTAGYNQDQVLEQGGLSSLFQA
LGVSVTPIQKVVLSGENGLKADIHVIIPYEGLSGFQMGLIEMIFKVVYPVDDHHFKIILH
YGTLVIDGVTPNMIDYFGRPYPGIAVFDGKQITVTGTLWNGNKIYDERLINPDGSLLFRV
TINGVTGWRLCENILA

BDBM223160

n/a

Name

BDBM223160

Synonyms:

Methyl trans-4-(4-(2-(ethyl(3-ethylphenyl)amino)-2-oxoethyl)-4H-thieno[3,2-b]pyrrole-5carboxamido)cyclohexane-1-carboxylate (22)

Type

Small organic molecule

Emp. Form.

C27H33N3O4S

Mol. Mass.

495.634

SMILES

CCN(C(=O)Cn1c(cc2sccc12)C(=O)N[C@H]1CC[C@@H](CC1)C(=O)OC)c1cccc(CC)c1 |r,wU:17.18,wD:20.25,(16.5,-21.06,;16.5,-19.52,;15.17,-18.75,;15.17,-17.21,;13.84,-16.44,;16.5,-16.44,;16.5,-14.9,;17.75,-14,;17.27,-12.53,;15.73,-12.53,;14.49,-11.63,;13.24,-12.53,;13.72,-14,;15.26,-14,;19.21,-14.48,;19.53,-15.98,;20.36,-13.45,;21.82,-13.92,;22.97,-12.89,;24.43,-13.37,;24.75,-14.87,;23.61,-15.9,;22.14,-15.43,;26.22,-15.35,;27.36,-14.32,;26.54,-16.86,;28,-17.33,;13.84,-19.52,;13.84,-21.06,;12.5,-21.83,;11.17,-21.06,;11.17,-19.52,;9.83,-18.75,;8.5,-19.52,;12.5,-18.75,)|

Structure