Ki Summary

Reaction Details

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Target

Oplophorus-luciferin 2-monooxygenase catalytic subunit

Ligand

BDBM223182

Substrate/Competitor

n/a

Meas. Tech.

NanoLuc Inhibition Assay

IC50

2.3±n/a nM

Citation

Walker, JR; Hall, MP; Zimprich, CA; Robers, MB; Duellman, SJ; Machleidt, T; Rodriguez, J; Zhou, W Highly Potent Cell-Permeable and Impermeable NanoLuc Luciferase Inhibitors. ACS Chem Biol12:1028-1037 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Oplophorus-luciferin 2-monooxygenase catalytic subunit

Name:

Oplophorus-luciferin 2-monooxygenase catalytic subunit

Synonyms:

19kOLase (EC:1.13.12.13) | LUCI_OPLGR | NanoLuc luciferase (Nluc)

Type:

Enzyme

Mol. Mass.:

21528.45

Organism:

Oplophorus gracilirostris (Luminous shrimp)

Description:

Q9GV45

Residue:

196

Sequence:

MAYSTLFIIALTAVVTQASSTQKSNLTFTLADFVGDWQQTAGYNQDQVLEQGGLSSLFQA
LGVSVTPIQKVVLSGENGLKADIHVIIPYEGLSGFQMGLIEMIFKVVYPVDDHHFKIILH
YGTLVIDGVTPNMIDYFGRPYPGIAVFDGKQITVTGTLWNGNKIYDERLINPDGSLLFRV
TINGVTGWRLCENILA

BDBM223182

n/a

Name

BDBM223182

Synonyms:

1-(2-(Ethyl(3-ethylphenyl)amino)-2-oxoethyl)-N-(trans-4-((6hydroxyhexyl)carbamoyl)cyclohexyl)-1H-indole-2-carboxamide (44)

Type

Small organic molecule

Emp. Form.

C32H44N4O4S

Mol. Mass.

580.781

SMILES

CCN(C(=O)Cn1c(cc2sccc12)C(=O)NC1CCC(CC1)C(=O)NCCCCCCO)c1cccc(CC)c1 |(54.27,-31.84,;54.27,-30.3,;52.94,-29.53,;52.94,-27.99,;51.6,-27.22,;54.27,-27.22,;54.27,-25.68,;55.52,-24.77,;55.04,-23.31,;53.5,-23.31,;52.25,-22.4,;51.01,-23.31,;51.48,-24.77,;53.02,-24.77,;56.98,-25.25,;57.3,-26.75,;58.13,-24.22,;59.59,-24.69,;59.91,-26.2,;61.37,-26.68,;62.52,-25.65,;62.2,-24.14,;60.73,-23.66,;63.98,-26.12,;65.13,-25.09,;64.3,-27.63,;65.77,-28.1,;66.09,-29.61,;67.55,-30.09,;67.87,-31.59,;69.34,-32.07,;69.66,-33.57,;71.12,-34.05,;51.6,-30.3,;50.27,-29.53,;48.94,-30.3,;48.94,-31.84,;50.27,-32.61,;50.27,-34.15,;51.6,-34.92,;51.6,-31.84,)|

Structure