| Reaction Details |
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 | Report a problem with these data |
| Target | Leukotriene C4 synthase |
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| Ligand | BDBM223288 |
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| Substrate/Competitor | LTC4 |
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| Meas. Tech. | In Vitro hLTC4 Synthase Enzyme Assay (Test B) |
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| pH | 7.5±n/a |
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| IC50 | 0.248±n/a nM |
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| Comments | extracted |
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| Citation |  Ronn, R; Lindh, CJ; Ringberg, E; Andersson, HB; Nilsson, P; Schaal, WR; Rosenschold, MM; Nikitidis, A; Nikitidis, G; Johannesson, P; Tyrcha, C Compounds and uses US Patent US20160326143 Publication Date 11/10/2016 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Leukotriene C4 synthase |
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| Name: | Leukotriene C4 synthase |
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| Synonyms: | LTC4 synthase | LTC4S | LTC4S_HUMAN | Leukotriene-C(4) synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 16575.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_961179 |
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| Residue: | 150 |
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| Sequence: | MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYF
PLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVA
LAALGLLAHFLPAALRAALLGRLRTLLPWA
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| BDBM223288 |
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| LTC4 |
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| Name | BDBM223288 |
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| Synonyms: | (1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-5-(trifluoromethyl)phenyl]amino}-3-methoxypyrazin-2-yl)carbonyl]cyclopropanecarboxylic acid | US20160326143, 63 | US9657001, 63 |
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| Type | Small Organic Molecule |
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| Emp. Form. | C21H20F5N3O4 |
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| Mol. Mass. | 473.3932 |
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| SMILES | COc1nc(cnc1C(=O)[C@H]1C[C@@H]1C(O)=O)N(CC(C)(C)F)c1cc(ccc1F)C(F)(F)F |
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| Structure | 
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