| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine deaminase |
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| Ligand | BDBM223291 |
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| Substrate/Competitor | Arabinofuranosyladenine (Ara-A) |
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| Meas. Tech. | In Vitro ADA Activity Assay |
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| pH | 7.2±n/a |
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| Temperature | 303.15±n/a K |
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| Ki | 1± 0.1 nM |
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| Comments | extracted |
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| Citation |  Wu, P; Wan, D; Xu, G; Wang, G; Ma, H; Wang, T; Gao, Y; Qi, J; Chen, X; Zhu, J; Li, YQ; Deng, Z; Chen, W An Unusual Protector-Protégé Strategy for the Biosynthesis of Purine Nucleoside Antibiotics. Cell Chem Biol24:171-181 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine deaminase |
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| Name: | Adenosine deaminase |
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| Synonyms: | Adenosine deaminase 3 (SanADA3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 38157.60 |
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| Organism: | Streptomyces antibioticus |
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| Description: | GenBank: KT591401.1 |
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| Residue: | 356 |
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| Sequence: | MTASRIDTETLRRLPKAVLHDHLDGGLRPATVVELAAAVGHTLPTTDPDELAAWYVEAAN
SGDLVRYIATFEHTLAVMQTREGLLRTAEEYVLDLAADGVVYAEVRYAPELMLKGGLTLT
EVVEAVQEGLAAGMAKAAAAGTPVRVGTLLCGMRMFDRVREAAGLAVAYRDAGVVGFDIA
GAEDGFPPADHLDAFAYLRAESMPFTIHAGEAYGLPSIHQALQVCGAQRIGHGVRLTEDI
VDGKLGRLASWVRDRRIALEMCPTSNLQTGCATSIAEHPITALKDLGFRVTLNTDNRLVS
GTTMTREMSLLVEQAGWTVEDLRTVTVNALKSAFVPFDERTALIEDVVLPGYAAAL
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| BDBM223291 |
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| Arabinofuranosyladenine (Ara-A) |
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| Name | BDBM223291 |
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| Synonyms: | Pentostatin (PTN) |
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| Type | Small organic molecule |
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| Emp. Form. | C11H16N4O4 |
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| Mol. Mass. | 268.2691 |
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| SMILES | OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2[C@H](O)CN=CNc12 |c:16| |
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| Structure | 
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