| Reaction Details |
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 | Report a problem with these data |
| Target | Insulin receptor substrate 1 [1-264] |
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| Ligand | BDBM223477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Silico Screening Assay |
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| Kd | 1990±n/a nM |
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| Citation |  Mahadevan, D; Meuillet, EJ; Mash, Jr., EA; Gokhale, VM; Powis, G; Zhang, S Small molecule inhibitors of the pleckstrin homology domain and methods for using same US Patent US9320734 Publication Date 4/26/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Insulin receptor substrate 1 [1-264] |
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| Name: | Insulin receptor substrate 1 [1-264] |
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| Synonyms: | IRS1 | IRS1_HUMAN | Insulin receptor substrate 1 (IRS1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 28998.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PLECKSTRIN HOMOLOGY DOMAIN, RESIDUES 1-264 (PH domain) |
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| Residue: | 264 |
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| Sequence: | MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEF
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| BDBM223477 |
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| n/a |
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| Name | BDBM223477 |
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| Synonyms: | US9320734, 316 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16ClN7O4S |
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| Mol. Mass. | 497.914 |
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| SMILES | CC1=NN(C(=O)c2ccc(Cl)cc2)C(=O)C1\N=N\c1ccc(cc1)S(=O)(=O)Nc1ncccn1 |t:1| |
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| Structure | 
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