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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM223502 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Inhibition Assay | ||
| IC50 | <100±n/a nM | ||
| Citation |  Ahn, JH; Pagire, HS; Rhee, SD; Kim, KY; Jung, WH; Bae, M; Song, JS; Kim, K; Kwak, HJ Beta-alanine derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical composition comprising same as active ingredient US Patent US9321728 Publication Date 4/26/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
| ||
| BDBM223502 | |||
| n/a | |||
| Name | BDBM223502 | ||
| Synonyms: | US9321728, 21 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H30F3N3O5 | ||
| Mol. Mass. | 557.5608 | ||
| SMILES | Cc1ccccc1-c1nc(C(=O)NCCC(=O)Nc2ccc(cc2)C2CC[C@H](CC(O)=O)CC2)c(o1)C(F)(F)F |r,wD:27.29,$;;;;;;;;;;;;HN;;;;;HN;;;;;;;;;;;;;;;;;;;;;;$,(-10.42,4.31,;-11.19,2.98,;-12.73,2.98,;-13.5,1.64,;-12.73,.31,;-11.19,.31,;-10.42,1.64,;-8.88,1.64,;-7.97,.4,;-6.51,.87,;-5.17,.1,;-5.17,-1.44,;-3.84,.87,;-2.51,.1,;-1.17,.87,;.16,.1,;.16,-1.44,;1.49,.87,;2.83,.1,;2.83,-1.44,;4.16,-2.21,;5.5,-1.44,;5.5,.1,;4.16,.87,;6.83,-2.21,;8.16,-1.44,;9.5,-2.21,;9.5,-3.75,;10.83,-4.52,;12.16,-3.75,;13.5,-4.52,;12.16,-2.21,;8.16,-4.52,;6.83,-3.75,;-6.47,2.44,;-7.97,2.89,;-5.23,3.34,;-3.98,4.25,;-6.13,4.59,;-4.32,2.1,)| | ||
| Structure | 
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