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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM223504 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Inhibition Assay | ||
| IC50 | <100±n/a nM | ||
| Citation |  Ahn, JH; Pagire, HS; Rhee, SD; Kim, KY; Jung, WH; Bae, M; Song, JS; Kim, K; Kwak, HJ Beta-alanine derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical composition comprising same as active ingredient US Patent US9321728 Publication Date 4/26/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM223504 | |||
| n/a | |||
| Name | BDBM223504 | ||
| Synonyms: | US9321728, 27 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H27BrF3N3O5 | ||
| Mol. Mass. | 622.43 | ||
| SMILES | OC(=O)C[C@H]1CCC(CC1)c1ccc(NC(=O)CCNC(=O)c2nc(oc2C(F)(F)F)-c2ccc(Br)cc2)cc1 |r,wD:4.3,(12.93,2.21,;12.93,3.75,;14.27,4.52,;11.6,4.52,;10.27,3.75,;8.93,4.52,;7.6,3.75,;7.6,2.21,;8.93,1.44,;10.27,2.21,;6.27,1.44,;4.93,2.21,;3.6,1.44,;3.6,-.1,;2.26,-.87,;.93,-.1,;.93,1.44,;-.4,-.87,;-1.74,-.1,;-3.07,-.87,;-4.4,-.1,;-4.4,1.44,;-5.74,-.87,;-7.2,-.4,;-8.11,-1.64,;-7.2,-2.89,;-5.65,-2.43,;-4.39,-3.32,;-3.13,-4.21,;-5.27,-4.58,;-3.5,-2.06,;-9.65,-1.64,;-10.42,-.31,;-11.96,-.31,;-12.73,-1.64,;-14.27,-1.64,;-11.96,-2.98,;-10.42,-2.98,;4.93,-.87,;6.27,-.1,)| | ||
| Structure | 
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