Ki Summary

Reaction Details

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Target

Lysophosphatidic acid receptor 1

Ligand

BDBM50398089

Substrate/Competitor

n/a

Meas. Tech.

Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay

Temperature

298.15±n/a K

IC50

58±n/a nM

Comments

extracted

Citation

Gabriel, SD; Hamilton, MM; Lucas, MC; Qian, Y; Sidduri, A N-alkyltriazole compounds as LPAR antagonists US Patent US9321738 Publication Date 4/26/2016

More Info.:

Get all data from this article, Assay Method

Lysophosphatidic acid receptor 1

Name:

Lysophosphatidic acid receptor 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

41120.55

Organism:

Homo sapiens (Human)

Description:

Q92633

Residue:

364

Sequence:

MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVC
IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND
HSVV

BDBM50398089

n/a

Name

BDBM50398089

Synonyms:

CHEMBL2182051 | US9321738, 14

Type

Small organic molecule

Emp. Form.

C26H30N4O4

Mol. Mass.

462.5408

SMILES

C[C@@H](OC(=O)Nc1c(nnn1C)-c1ccc(cc1)C1CCC(CC(O)=O)CC1)c1ccccc1 |r,wD:1.0,(51.8,-50.88,;51.04,-52.22,;49.5,-52.23,;48.72,-50.9,;49.48,-49.56,;47.18,-50.91,;46.4,-49.58,;44.94,-49.14,;44.9,-47.61,;46.34,-47.1,;47.28,-48.32,;48.82,-48.29,;43.57,-49.86,;43.51,-51.4,;42.15,-52.11,;40.85,-51.28,;40.92,-49.74,;42.28,-49.03,;39.48,-51.99,;39.42,-53.53,;38.05,-54.24,;36.75,-53.41,;35.38,-54.12,;34.08,-53.29,;32.71,-54,;34.15,-51.75,;36.82,-51.86,;38.19,-51.16,;51.82,-53.55,;51.06,-54.88,;51.83,-56.21,;53.38,-56.2,;54.14,-54.85,;53.35,-53.52,)|

Structure