| Reaction Details |
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 | Report a problem with these data |
| Target | Sialidase A |
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| Ligand | BDBM4994 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Sialidase Assay |
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| pH | 9±n/a |
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| Ki | 1.77e+3±n/a nM |
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| Comments | extracted |
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| Citation |  Hayre, JK; Xu, G; Borgianni, L; Taylor, GL; Andrew, PW; Docquier, JD; Oggioni, MR Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases. BMC Biochem13:19 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sialidase A |
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| Name: | Sialidase A |
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| Synonyms: | NANA_STREE | Neuraminidase A (NanA) | Sialidase A | nanA |
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| Type: | Enzyme |
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| Mol. Mass.: | 114737.08 |
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| Organism: | Streptococcus pneumoniae |
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| Description: | P62576; spr1536 |
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| Residue: | 1035 |
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| Sequence: | MSYFRNRDIDIERNSMNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASEQ
PLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVET
VIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKD
EYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAELPKGRVR
LYVNGVLSRTSLRSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTVYNRALTPEE
VQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLI
AGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMVL
VQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGT
VYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIYFTTNKTSPFRIAKDSYLWMSY
SDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNG
SQSSRIIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKL
FMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPK
RENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLS
FRKFNWDFLSKDLISPTEAKVKRTREMGKGVIGLEFDSEVLVNKAPTLQLANGKTARFMT
QYDTKTLLFTVDSEDMGQKVTGLAEGAIESMHNLPVSVAGTKLSNGMNGSEAAVHEVPEY
TGPLGTSGEEPAPTVEKPEYTGPLGTSGEEPAPTVEKPEYTGPLGTAGEEAAPTVEKPEF
TGGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLT
AFFLGLFTLGKKREQ
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| BDBM4994 |
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| n/a |
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| Name | BDBM4994 |
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| Synonyms: | (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid | CHEMBL674 | GS4071 | Oseltamivir carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C14H24N2O4 |
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| Mol. Mass. | 284.3514 |
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| SMILES | CCC(CC)O[C@@H]1C=C(C[C@H](N)[C@H]1NC(C)=O)C(O)=O |r,c:7| |
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| Structure | 
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