| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-glucosidase MAL32 |
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| Ligand | BDBM225289 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro α-Glucosidase Inhibitory Assay |
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| pH | 6.8±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 5.98e+3± 1.1e+2 nM |
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| Citation |  Wang, G; Wang, J; Xie, Z; Chen, M; Li, L; Peng, Y; Chen, S; Li, W; Deng, B Discovery of 3,3-di(indolyl)indolin-2-one as a novel scaffold for a-glucosidase inhibitors: In silico studies and SAR predictions Bioorg Chem72:228-233 (2017) |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-glucosidase MAL32 |
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| Name: | Alpha-glucosidase MAL32 |
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| Synonyms: | Alpha-glucosidase MAL32 | MAL32 | MAL32_YEAST | MAL3S | Maltase | alpha-Glucosidase (α-Glucosidase) | alpha-Glucosidase (alpha-Glu) | alpha-Glucosidase (α-Glucosidase) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 68132.36 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | Purchased from Wako Fine Chemicals Co. Ltd. |
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| Residue: | 584 |
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| Sequence: | MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCP
FYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFK
ESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASR
QVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHP
NWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSF
THVELGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADD
SPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSF
GKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFFLNESFEQGINVEQ
ESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNF
SGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
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| BDBM225289 |
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| n/a |
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| Name | BDBM225289 |
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| Synonyms: | 1,1''-bis(2-Fluorobenzyl)-[3,3':3',3''-terindolin]-2'-one (4j) |
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| Type | Small organic molecule |
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| Emp. Form. | C38H27F2N3O |
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| Mol. Mass. | 579.6373 |
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| SMILES | Fc1ccccc1Cn1cc(c2ccccc12)C1(C(=O)Nc2ccccc12)c1cn(Cc2ccccc2F)c2ccccc12 |
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| Structure | 
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